Place chicken tenders in buttermilk and refrigerate for 30 minutes to tenderize.
Mix flour, panko, garlic powder, smoked paprika, and black pepper in a shallow dish.
Remove tenders from buttermilk, letting excess drip off, then coat each piece thoroughly in the flour mixture.
Heat avocado oil in a large skillet over medium-high heat to 350°F / 175°C.
Fry tenders for 6 to 7 minutes per side until golden brown and internal temperature reaches 165°F / 74°C.
Transfer to a wire rack and rest for 5 minutes before serving with your favorite dipping sauce.