Combine chicken tenders, buttermilk, garlic powder, and smoked paprika in a bowl, cover, and refrigerate for 10 minutes.
Mix flour, panko breadcrumbs, and black pepper in a shallow dish.
Remove chicken from buttermilk, letting excess drip off, then press each tender into the flour mixture until fully coated.
Heat avocado oil in a large skillet over medium-high heat until shimmering.
Fry chicken tenders for 6 to 7 minutes per side until golden brown and cooked to 165°F / 74°C at the thickest part.
Transfer tenders to a wire rack and rest for 5 minutes before serving with your favorite dipping sauce.