Place the chicken breast in a large skillet and add chicken broth, garlic powder, onion powder, cumin, smoked paprika, salt, and black pepper.
Bring to a boil over high heat, then reduce to medium heat and simmer for 8 to 10 minutes until the chicken reaches 165°F / 74°C at the thickest part.
Remove the chicken from the skillet and let rest for 2 minutes on a cutting board.
Shred the chicken using two forks, pulling the meat apart into thin strands.
Toss the shredded chicken with 2 to 3 tablespoons of the cooking liquid to keep it moist, then use immediately in tacos, wraps, bowls, or casseroles.